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Eight Brazil players and three from Argentina will be among the Premier League's South American contingent representing their countries in the early hours of Friday morning.

The following day, Liverpool are resigned to being without goalkeeper Alisson and midfielder Fabinho at Watford. Manchester City are likely to face Burnley without Ederson and Gabriel Jesus. Chelsea are expected to miss Thiago Silva, Manchester United Fred, and Leeds Raphina.

Aston Villa No 1 Emiliano Martinez is a doubt for his side’s game with Wolves.

And though Tottenham’s Brazilian Emerson Royal and Argentinians Giovani Lo Celso and Cristian Romero have longer to recover because their club plays on Sunday, a 12-hour flight through different time zones is no preparation for a Premier League fixture.